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ASCEND is co-ordinated by CTSU which It is funded by the Medical Research Council, which supports an embedded MRC unit, as well as by grants from the British Heart Foundation and from Cancer Research UK. Funding for this study is provided by the British Heart Foundation to cover the administrative and coordination costs of the trial. Aspirin and matching placebo is being provided by Bayer Healthcare AG, and omega-3 fatty acid and matching placebo capsules by Mylan (previously Solvay Pharmaceuticals), with some funding from each company to cover drug packaging. Alzheimer's Research UK have provided a grant to measure cognitive fuction in ASCEND participants. The University of Oxford is acting as the sponsor of this study.